Located in the Piedmont Region of South Carolina, the town of Ninety Six is located in Greenwood County. The town was established in 1730 in the backcountry at the crossroads of an important trade route. It derived its name from traders believing that it was 96 miles to the nearest Cherokee settlement of Keowee.
The National Park Service operates the Ninety Six National Historic Site at the location of the original frontier settlement and the first land battle of the Revolution in the South in 1775 and in 1780. The present town of Ninety Six lies just north of the original settlement. Nearby is Lake Greenwood, an 11,400-acre reservoir which includes Lake Greenwood State Recreation Area.